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For example, an athlete engaging in a very strenuous workout – say, a full-contact football practice, for instance – will have supplemented creatine in his body for slightly less than one hour, provided the person ingested the standard 1-tbsp. Drinking just loosens me up while tripping, just dont drink too much aka dont get drunk/hammered. There's a higher concentration under the tongue than in the esophagus. 100% Secure and Anonymous. Abstain from orgasm (for a day or two). May take 1-4 days for full effect. You may feel that drinking milk might help but its high calcium content will only make things worse. It is recommended that you not take more than your initial dose until at least 2 hours later given the delayed effect. Omega-3 fatty acid supplementation for rheumatoid arthritis does not work as quickly as it does for heart health. Mini Ladd 1,927,905 views. It does contain aspirin which is absorbed. 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Even if you drop it immediately and take a quick drive somewhere, you never know how quickly the substance might take effect.